Raman downstream process measurement of biosimilars
Alvotech’s testing of the protein purification process during ultrafiltration/diafiltration (UF/DF)
Find out how Alvotech is enhancing its downstream processing for biosimilar production by enabling real-time monitoring of the protein purification process during UF/DF. The result? The company can realize cost savings, faster processing, and more proactive decision making for increased efficiency.
Benefits can include:
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Cost savings: reduced labor, buffer solution, and offline analysis costs lead to significant savings
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Faster processing time: real-time monitoring and adjustment of the UF/DF process eliminate process pauses, resulting in streamlined operations
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Process optimization: instant analytical results enable proactive decision-making, enhancing overall efficiency
Customer challenges
Downstream phase process development requires a PAT that accommodates reduced volumes and shorter cycle times. However, efficiency improvements for downstream applications are hindered by technological challenges, such as reliance on extractive analytical methods for composition measurement, slow response times, insufficient nominal ranges, background interferences, and more. The complexity of purification steps, driven by intensified upstream processes, needs innovative downstream solutions.
Our solution
Alvotech chose Endress+Hauser to test in-line Raman spectroscopy in upstream and downstream process development. The selected Raman system is tailored for downstream flow paths, leveraging signal amplification and low-noise technology to deliver faster results. It consists of the following components:
Raman Rxn2 analyzer
Rxn-10 probe
Raman flow assembly
Povezana ponuda
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Jednostavni proizvodi
- Jednostavno je odabrati, instalirati i rukovati
Tehnička izvrsnost
Jednostavnost
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Standardni proizvodi
- Pouzdano, robustno i s malo održavanja
Tehnička izvrsnost
Jednostavnost
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Specijalizirani proizvodi
- Dizajnirano za zahtjevne aplikacije
Tehnička izvrsnost
Jednostavnost
Promjenjivo
| FLEX odabir | Tehnička izvrsnost | Jednostavnost |
|---|---|---|
Fundamental odabir Udovoljite svojim osnovnim potrebama u mjernju |
Tehnička izvrsnost
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Jednostavnost
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Lean odabir Jednostavno upravljajte svojim osnovnim procesima |
Tehnička izvrsnost
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Jednostavnost
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Extended odabir Optimizirajte svoje procese s inovativnim tehnologijama |
Tehnička izvrsnost
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Jednostavnost
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Xpert odabir Ovladajte svojim najizazovnijim aplikacijama |
Tehnička izvrsnost
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Jednostavnost
Promjenjivo |